Malignancy and Immunosuppression [Abstract]

Immunosuppression and Malignancy

The increasing use over the past decade of powerful immunosuppressive drugs provides an opportunity for testing the validity of the theory that cancer results from a breakdown of the body's "immunological surveillance." This concept, first proposed by L. Thomas' and since developed by Sir Macfarlane Burnet,2 holds that such a breakdown allows the proliferation of abnormal cells, with the eventu...

Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients.

The success of renal transplantation may be counterbalanced by serious adverse medical events. The effect of immunosuppression on the incidence of de novo neoplasms among kidney recipients should be monitored continuously. Using data from the Scientific Registry of Transplant Recipients, we studied the association of induction therapy by immunosuppression with antilymphocyte antibodies, with th...

Urinary Melatonin Levels and Skin Malignancy

Melatonin inhibits tumor genesis in a variety of in vivo and in vitro experimental models of neoplasia. In industrialized societies, light at night, by suppressing melatonin production, poses a new risk for the development of a variety of cancers such as breast cancer. This effect on skin has been previously studied only in animals and not in humans. Our goal was to examine the relationship bet...

abstract

ABSTRACT